Effect of nucleoside-5'-phosphates on collagen-induced in vitro mineralization.
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2004-08-03
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Abstract
Nucleoside triphosphates (NTPs) at 4-10 microM concentrations were found to inhibit the rates of collagen-induced in vitro mineralization and ion exchange reactions. The sequential removal of the terminal phosphate groups caused a step-wise decrease in their inhibitory potency. The results suggest that NTPs inhibit the rates of ion uptake and exchange reactions at concentrations much lower than their intracellular physiological concentrations. Thus NTPs may be involved in the control of biological mineralization and the tissues which mineralize under physiological conditions develop a system to locally convert NTPs to NDPs and NMPs.
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Talwar HS, Singla SK, Tandon C, Jethi RK. Effect of nucleoside-5'-phosphates on collagen-induced in vitro mineralization. Indian Journal of Experimental Biology. 2004 Aug; 42(8): 844-6