Biochemical alterations in rat fetal liver following in utero exposure to di(2-ethylhexyl)phthalate (DEHP).

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Date
1989-10-01
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Abstract
Oral administration of DEHP, 1000 mg/kg body weight, to rats daily from 6 to 15 day of gestation resulted in retardation of fetal growth and increase in fetal liver weight which contained significant quantities of DEHP. The activities of mitochondrial succinate dehydrogenase, malate dehydrogenase, cytochrome c oxidase and adenosine triphosphatase were decreased in fetal liver. The data indicate that exposure of mothers to DEHP during pregnancy could adversely affect the fetal livers by interfering with bioenergetics of the cell.
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Srivastava S, Awasthi VK, Srivastava SP, Seth PK. Biochemical alterations in rat fetal liver following in utero exposure to di(2-ethylhexyl)phthalate (DEHP). Indian Journal of Experimental Biology. 1989 Oct; 27(10): 885-8
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https://imsear.searo.who.int/handle/123456789/57051
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Indian Journal of Experimental Biology