Caffeine inhibits the development of Ehrlich ascites carcinoma cells in female mice.

No Thumbnail Available
Date
2001-08-23
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Long-term administration of caffeine at a dose of 20 mg /kg/day p.o. suppressed the viability, oxygen consumption and [3H]-thymidine incorporation of Ehrlich ascites carcinoma (EAC) cells. Though no significant change in the levels of plasma and adrenal corticosterone as well as both total and reduced adrenal ascorbic acid were observed following long-term caffeine consumption, pretreatment of caffeine and continuation of its treatment in the course of development of EAC cells restored the EAC Cell-induced changes in both corticosterone and ascorbic acid levels to control values. These results, thus, suggest that caffeine may suppress the growth of EAC cells by modulating the adrenal ascorbate level as well as corticosterone status.
Description
Keywords
Citation
Mukhopadhyay S, Poddarr MK. Caffeine inhibits the development of Ehrlich ascites carcinoma cells in female mice. Indian Journal of Experimental Biology. 2001 Aug; 39(8): 735-41
URI
https://imsear.searo.who.int/handle/123456789/56820
Collections
Indian Journal of Experimental Biology