Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.

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Date
2005-04-07
Authors
Kumar, G
Banu, G Sharmila
Kannan, V
Pandian, M Rajasekara
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Abstract
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
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Kumar G, Banu GS, Kannan V, Pandian MR. Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats. Indian Journal of Experimental Biology. 2005 Apr; 43(4): 351-5
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https://imsear.searo.who.int/handle/123456789/55793
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Indian Journal of Experimental Biology