Role of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy.

Desikan, P; Parkash, O; Narang, P

Role of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy.

Date

1995-07-01

Authors

Desikan, P

Parkash, O

Narang, P

Abstract

This study was carried out in order to find out whether antineural antibodies had a role to play in perpetuating pre-existing nerve damage in leprosy. Indirect ELISA was carried out on sera from 20 leprosy patients and five normal controls using antigen prepared from peripheral nerves of a cured bacteriologically negative leprosy patient. None of the patients had significant levels of IgG antibodies whereas eight of them (40%) had significant levels of IgM antibodies. However, there was no correlation with duration of disease, treatment received, nerve enlargement or active neuritis. The nature of these antibodies is discussed.

Citation

Desikan P, Parkash O, Narang P. Role of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy. Indian Journal of Leprosy. 1995 Jul-Sep; 67(3): 293-300