Dapsone syndrome in Goa.
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Date
1994-01-01
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Abstract
Daspone syndrome was noted within six weeks of starting treatment in 1.3% of about 700 leprosy patients on MDT reporting to the skin department of Goa Medical College. Skin rash, photosensitivity, fever, lymphadenopathy, sore throat, hepatosplenomegaly, abnormal liver function tests and raised reticulocyte count were consistent features in all the patients. Other drugs, infectious mononucleosis and viral exanthemata were considered in differential diagnosis. Withdrawal of dapsone and administration of prednisolone controlled the condition within three to four weeks in majority of the patients. One patient died of ischemic heart disease unrelated to dapsone syndrome.
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Rege VL, Shukla P, Mascarenhas MF. Dapsone syndrome in Goa. Indian Journal of Leprosy. 1994 Jan-Mar; 66(1): 59-64