Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone.

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1985-10-01
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Abstract
Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.
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Kulkarni VM, Mishra DS. Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone. Indian Journal of Leprosy. 1985 Oct-Dec; 57(4): 756-62