In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
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1991-04-01
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Abstract
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
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Dhople AM, Lamoureux LC, Gardner GD. In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy. Indian Journal of Leprosy. 1991 Apr-Jun; 63(2): 166-79