Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis.

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Date
2009-01-28
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Abstract
T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3+/gamma-delta (gammadelta) TCR+ and CD3+/alpha-beta (alphabeta) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3+ and CD3+/alphabeta TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3+/gammadelta and CD3+/alphabeta TCR+ were not statistically different between active and inactive PT patients. It was concluded that alphabeta TCR+ T cells might have a protective role in tuberculosis infection.
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Akbulut HH, Deveci F, Celik I, Ilhan F, Turgut T. Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis. Indian Journal of Medical Microbiology. 2009 Jan-Mar; 27(1): 40-3
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https://imsear.searo.who.int/handle/123456789/53930
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Indian Journal of Medical Microbiology