Nephrogenic fibrosing dermopathy.
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2009-01-28
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Abstract
An adult female patient on hemodialysis for chronic renal failure presented with large, brownish, and indurated plaques with bound-down skin on both lower limbs and abdomen along with difficulty in movement of the legs. Histopathological features revealed thick collagen bundles admixed with mucin and intercalating spindle-like cells characteristic of nephrogenic fibrosing dermopathy (NFD). Immunohistochemical study showed prominent CD68 positivity and weak CD34 positivity suggesting that the plaques were more than 20-weeks old. NFD in patients with chronic renal failure of unknown cause is a poor prognostic indicator. Early detection before the development of contracture and prompt treatment of NFD and underlying renal failure may reverse this disabling condition.
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Ragunatha S, Palit A, Inamadar AC, Madraki RM, Yelikar BR. Nephrogenic fibrosing dermopathy. Indian Journal of Dermatology, Venereology and Leprology. 2009 Jan-Feb; 75(1): 63-7