Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy.

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Date
2008-01-12
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Abstract
BACKGROUND AND AIMS: Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified. METHODS: In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool. RESULTS: According to this study, nine strong possible ligands can be identified. CONCLUSION: These sites can be useful for further drug-development studies.
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Wiwanitkit V. Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy. Indian Journal of Dermatology, Venereology and Leprology. 2008 Jan-Feb; 74(1): 32-4
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https://imsear.searo.who.int/handle/123456789/52980
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Indian Journal of Dermatology, Venereology and Leprology