Anticonvulsant hypersensitivity syndrome study of 60 cases.

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Date
2001-11-01
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Abstract
Sixty patients of anticonvulsant hypersensitivity syndrome were studied. Fever and skin rash were present in all patients with peripheral blood leucocytosis and eosinophilia in 30 patients. Phenytoin was the commonest offending drug(39 patients) followed by carbamazepine (19 patients). AHS appeared after 2-12 weeks of the intake of offending drugs. Head injury was the primary illness in 43 patients (70 per cent) followed by brain tumors (9 patients). Cross reactivity between phenytoin and carbamazepine was seen in 3 patients. Most patients recovered well with withdrawal of the offending drugs and treatment with topical corticosteroids and antihistamines. There was only one fatality.
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Bhargava P. Anticonvulsant hypersensitivity syndrome study of 60 cases. Indian Journal of Dermatology, Venereology and Leprology. 2001 Nov-Dec; 67(6): 317-9
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https://imsear.searo.who.int/handle/123456789/52357
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Indian Journal of Dermatology, Venereology and Leprology