Simultaneous occurrence of toxic epidermal necrolysis and neuroleptic malignant syndrome.

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2005-07-06
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Abstract
Toxic epidermal necrolysis (TEN) is an acute life-threatening blistering disease characterized by involvement of the skin, multiple mucous membranes and internal organs. It is most commonly precipitated by the administration of medications like anticonvulsants. Neuroleptic malignant syndrome (NMS) is a rare complication of neuroleptic therapy characterized by catatonic behavior, generalized muscular rigidity, hyperthermia and autonomic dysfunction. An 18-year-old girl presenting with simultaneous appearance of TEN and NMS following anti-psychotic drugs given for bipolar mood disorder, is reported for the rare association and her complete recovery.
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Muhammed K, Raman P. Simultaneous occurrence of toxic epidermal necrolysis and neuroleptic malignant syndrome. Indian Journal of Dermatology, Venereology and Leprology. 2005 Jul-Aug; 71(4): 270-2