Prevalence of prostatic intraepithelial (PIN) in surgical resections.

de Silva, M V; Fernando, M S; Abeygunasekera, A M; Serozsha Goonewardene, S A

Prevalence of prostatic intraepithelial (PIN) in surgical resections.

Date

1998-12-01

Authors

de Silva, M V

Fernando, M S

Abeygunasekera, A M

Serozsha Goonewardene, S A

Abstract

OBJECTIVES: To determine the prevalence of prostatic intraepithelial neoplasia (PIN) in surgical specimens and assess its relationship to adenocarcinoma. METHOD: 205 surgical specimens (191) transurethral resections, 6 open prostatectomies, 8 needle biopsies) reported at the University Department of Pathology, Colombo over 64 months were reviewed. RESULTS: There were 170 benign hyperplasias and 35 adenocarcinomas. PIN I was present in 22.92% PIN II in 5.36% and PIN III in 7.32% of the specimens. 8.51%, 27.27% and 93.3% PIN I, PIN II and III were associated with invasive adenocarcinoma. Nine cases (4.39%) had high grade PIN (PIN II & III) in the absence of adenocarcinoma. CONCLUSION: PIN II & III were strongly associated with coexistent carcinoma but PIN I was not. The finding of high grade PIN in surgical biopsies with no obvious adenocarcinoma warrants examination of all available tissue and deep sections.

Citation

de Silva MV, Fernando MS, Abeygunasekera AM, Serozsha Goonewardene SA. Prevalence of prostatic intraepithelial (PIN) in surgical resections. Indian Journal of Cancer. 1998 Dec; 35(4): 137-41