Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary study).

Mansjoer, Arif; Alwi, Idrus; Subekti, Imam; Kasjmir, Yoga Iwanoff

Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary study).

Date

2007-10-30

Authors

Mansjoer, Arif

Alwi, Idrus

Subekti, Imam

Kasjmir, Yoga Iwanoff

Abstract

AIM: to determine the correlation between free thyroid hormone level and left ventricular ejection fraction in newly diagnosed Graves' patients. METHODS: this is a preliminary study with an initial cross-sectional design using free thyroxine level as a parameter of thyroid hormone state and left ventricular ejection fraction (LVEF) as a parameter of left ventricular systolic function. Free thyroxine level was measured in the laboratory and the LVEF was assessed by Simpson's methods of echocardiography study. RESULTS: ten patients (7 men and 3 women; age 18-52 years old) were studied. Their average of fT4 was 5.75 (SD 0.96) ng/dL and their average of LVEF was 70.57 (SD 4.50)%. There was positive correlation coefficient between free thyroxine level and left ventricular ejection fraction (r=0.711, p=0.021) in newly diagnosed Graves' patients. CONCLUSION: in this study strong positive correlation was found between free thyroxine (fT4) and left ventricular ejection fraction (LVEF) in newly diagnosed Graves' patients.

Citation

Mansjoer A, Alwi I, Subekti I, Kasjmir YI. Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary study). Acta Medica Indonesiana. 2007 Oct-Dec; 39(4): 163-8