Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais.
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Date
1999-11-05
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Abstract
In the next century, the increasing number of elderly and rising healthcare costs will bring with it metabolic bone problems, particularly osteoporosis. Deoxypyridinoline: Dpd in urine is a sensitive and specific marker for screening and monitoring of bone resorption in a variety of diseases affecting bone turnover and in risk groups especially in the postmenopause. The reference value among aging (21-60 years) of a healthy well defined group was studied by collecting the urine between 700-1000 hours and using the ELISA technique to determine the level of Dpd. The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm Creatinine respectively. The level of Dpd in females was significantly higher than in males at p < 0.028. However, the average value of deoxypyridinoline in postmenopause was higher than premenopause but not different at p = 0.05. There are many factors which influence the results so the overall reference value is only a guideline for screening in bone resorption.
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Chotmaihet Thangphaet.
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Pidetcha P, Intramanee S, Patrakarn K, Leelahakul P, Fongsupa S. Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais. Journal of the Medical Association of Thailand. 1999 Nov; 82(11): 1136-41