Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection?

Krobbuaban, Banjong; Siriwan, Diregpoke; Kumkeaw, Sujarit; Tanomsat, Malin; Jamjamrat, Gaison; Thanetses, Kaewan; Kosittanasan, Surangrat

Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection?

Date

2008-03-26

Authors

Kosittanasan, Surangrat

Abstract

BACKGROUND: Propofol formulated with medium- and long-chain triglycerides (MCT/LCT) causes less pain on injection than standard Propofol, but the incidence of pain persists between 28 and 67 percent. Such a broad range begs the question so the authors wanted to clarify whether the addition of lidocaine to medium- and long-chain triglyceride emulsion propofol results in any clinically significant lessening of pain on injection. The authors conducted a randomized, prospective, double-blinded study to compare the injection pain felt following the administration of propofol-MCT/LCT (Propofol-Lipuro) to propofol-MCT/LCT plus 20 mg lidocaine for the induction of anesthesia. MATERIAL AND METHOD: The present study included 270 non-premedicated ASA I-II adult patients scheduledfor elective surgery under general anesthesia. Patients were allocated randomly into two groups to receive either propofol-MCT/LCT alone or propofol-MCT/LCT plus 20 mg lidocaine. The study solution was injected at 1 mL/second by one anesthesiologist and patients graded any associated pain using a four-point scale. RESULTS: The overall incidence of pain on injection was 31/133 (23%) in the propofol-MCT/LCT plus lidocaine group vs. 45/135 (33%) in the propofol-MCT/LCT alone group. The difference in the incidence of pain on injection between groups failed to achieve statistical significance (p = 0.23) and no significant difference in intensity of pain between the two study groups occurred CONCLUSIONS: The authors concluded that the addition of lidocaine (20 mg) to the propofol-MCT/LCT does not significantly reduce the incidence or severity of the pain on injection.

Description

Chotmaihet Thangphaet.

Citation

Krobbuaban B, Siriwan D, Kumkeaw S, Tanomsat M, Jamjamrat G, Thanetses K, Kosittanasan S. Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection? Journal of the Medical Association of Thailand. 2008 Mar; 91(3): 383-7