Primary cardiac angiosarcoma with systemic metastases; a case report and review of the literature.

Larbcharoensub, Noppadol; Singhsnaeh, Arunee; Leelachaikul, Paisan

Primary cardiac angiosarcoma with systemic metastases; a case report and review of the literature.

Date

2004-09-02

Authors

Larbcharoensub, Noppadol

Singhsnaeh, Arunee

Leelachaikul, Paisan

Abstract

Angiosarcoma is a relatively uncommon primary malignant tumor of the heart derived from the endothelial cells. The authors report a case of primary cardiac angiosarcoma of the right atrium with pulmonary, hepatic, cerebellar and bony metastases in a 46-year-old man who clinically presented as pulmonary hemorrhage. The patient's occupational history had occasional exposure to polyvinyl chloride. The autopsy examination of the cardiac angiosarcoma characterized macroscopically by a right atrial tumor and histologically by anastomosing vascular channels and minute atypical pleomorphic endothelial cells. Immunohistological stainings were positive CD31, CD34 and focal positive factor VII-related antigen. Clinical and pathologic features with briefly reviewed relevant literatures are discussed This is the first reported description in the literature of a primary cardiac angiosarcoma with systemic metastases to multiple organs in Thailand.

Description

Chotmaihet Thangphaet. 26 references.

Citation

Larbcharoensub N, Singhsnaeh A, Leelachaikul P. Primary cardiac angiosarcoma with systemic metastases; a case report and review of the literature. Journal of the Medical Association of Thailand. 2004 Sep; 87(9): 1116-22