Maternal and umbilical cord serum vitamin A, E levels and mother-to-child transmission in the non-supplemented vitamin A, E HIV-1 infected parturients with short-course zidovudine therapy.
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1999-09-24
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Abstract
This study was undertaken to assess the maternal and umbilical cord serum vitamin A, E levels at delivery and mother-to-child transmission in nonsupplemented vitamin A, E HIV-1 infected parturients who received short-course zidovudine therapy. Maternal and umbilical cord serum vitamin A, E levels were quantitated by high-performance liquid chromatography in 67 HIV-1 infected parturients who received short-course zidovudine therapy. Mother-to-child transmission occurred in 13.4 per cent of HIV-1 infected parturients. There were no significant differences in the mean concentrations of vitamin A, E and vitamin E/cholesterol ratio between parturients with HIV-1 infected and non-infected infants. While maternal serum vitamin E level was adequate, nearly one-third of the parturients in the study had vitamin A deficiency. In conclusion our study has shown that there was no correlation between maternal serum vitamin A, E levels and mother-to-child HIV transmission in HIV-1 infected parturients who received short-course zidovudine therapy. However, the presence of underlying vitamin A deficiency in these parturients was common, adequate and intensive maternal-infant nutritional support should be emphasized especially in developing countries as an adjunctive measure in the reduction of mother-to-child transmission of HIV as well as the reduction in maternal and perinatal morbidity.
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Chotmaihet Thangphaet.
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Wiratchai A, Phuapradit W, Sunthornkachit R, Chaovavanich A, Tantanathip P, Puchaiwatananon O. Maternal and umbilical cord serum vitamin A, E levels and mother-to-child transmission in the non-supplemented vitamin A, E HIV-1 infected parturients with short-course zidovudine therapy. Journal of the Medical Association of Thailand. 1999 Sep; 82(9): 885-90