Loss of heterozygosity for chromosome 11 in Epstein-Barr-virus associated nasopharyngeal carcinoma.

Mutirangura, A; Tanunyutthawongese, C; Kerekhanjanarong, V; Sriuranpong, V; Pornthanakasem, W; Yenrudi, S; Supiyaphun, P; Voravud, N

Loss of heterozygosity for chromosome 11 in Epstein-Barr-virus associated nasopharyngeal carcinoma.

Date

1996-12-01

Authors

Mutirangura, A

Tanunyutthawongese, C

Abstract

In order to demonstrate and define possible tumor suppressor gene loci on chromosome 11 associated with NPC, we used 7 STR to test for LOH on 25 NPC samples. LOH was detected in 46 per cent of cases. Most LOH loci were clustered on the long arm. Further study demonstrated 22 per cent and 45.5 per cent of cases with LOH on 11q13 and 11q23 respectively.

Description

Chotmaihet Thangphaet.

Citation

Mutirangura A, Tanunyutthawongese C, Kerekhanjanarong V, Sriuranpong V, Pornthanakasem W, Yenrudi S, Supiyaphun P, Voravud N. Loss of heterozygosity for chromosome 11 in Epstein-Barr-virus associated nasopharyngeal carcinoma. Journal of the Medical Association of Thailand. 1996 Dec; 79 Suppl 1(): S65-70