Update in pathophysiology and histopathology of focal segmental glomerulosclerosis.

Kanjanabuch, Talerngsak; Lewsuwan, Songkiat; Kitiyakara, Chagriya; Cheunsuchon, Boonyarit; Eiam-Ong, Somchai

Update in pathophysiology and histopathology of focal segmental glomerulosclerosis.

Date

2006-08-19

Authors

Kanjanabuch, Talerngsak

Lewsuwan, Songkiat

Kitiyakara, Chagriya

Cheunsuchon, Boonyarit

Eiam-Ong, Somchai

Abstract

Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome in an adult worldwide. The prevalence of FSGS is estimated as being 20-30% in adults over the age of 15 years and slightly higher (30-35%) in the elderly (age > 60 years). The diagnosis solely relies on pathologic findings, which sclerosis involves some, but not all glomeruli (focal), and sclerosis affects a portion, but not the entire, glomerular tuft (segmental). The pathogenesis remains inconclusive but podocyte injury has been postulated. Even though steroid is the mainstay treatment, only 20-40% of patients are complete respond.

Description

Chotmaihet Thangphaet. 56 references.

Citation

Kanjanabuch T, Lewsuwan S, Kitiyakara C, Cheunsuchon B, Eiam-Ong S. Update in pathophysiology and histopathology of focal segmental glomerulosclerosis. Journal of the Medical Association of Thailand. 2006 Aug; 89 Suppl 2(): S262-79