Empirical antibiotic therapy in febrile neutropenic patients with single-daily dose amikacin plus ceftriaxone.
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1993-06-01
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Abstract
Hematologic malignancies and cancer patients who become neutropenic as a result of disease or myelosuppressive cytotoxic therapy are at a high risk of developing life-threatening infections, and hence empirical antibiotic therapy is administered promptly. We investigated once daily regimen of amikacin, for dose-dependent bactericidal activity and post-antibiotic effects, plus ceftriaxone, with a long-half life to maximise time-dependent bactericidal activity. Microbiologically proven septicemia were 11 out of 49 febrile episodes (22.5%) and 10 (91%) of these were due to gram-negative bacilli, mostly Enterobacteriaceae. The overall success of the regimen was 63.3 per cent of patients, with no significant toxicity. In conclusion, our findings suggest that once-daily administration of amikacin plus ceftriaxone in the initial treatment of febrile episodes in neutropenic patients produces satisfactory results and more cost-effective compared with other antibiotic regimens requiring 3-4 doses a day.
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Chotmaihet Thangphaet.
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Suwangool P, Aswapokee N, Sathapatayavongs B, Leelasuphasri S, Siritanaratkul N, Chuncharunee S, Chayakul P. Empirical antibiotic therapy in febrile neutropenic patients with single-daily dose amikacin plus ceftriaxone. Journal of the Medical Association of Thailand. 1993 Jun; 76(6): 314-8