Hb G Makassar (beta 6:Glu-Ala) in a Thai family.

Sangkitporn, Siripakorn; Rerkamnuaychoke, Budsaba; Sangkitporn, Somchai; Mitrakul, Chartchai; Sutivigit, Yavamal

Hb G Makassar (beta 6:Glu-Ala) in a Thai family.

Date

2002-05-22

Authors

Sangkitporn, Siripakorn

Rerkamnuaychoke, Budsaba

Sangkitporn, Somchai

Mitrakul, Chartchai

Sutivigit, Yavamal

Abstract

Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG-->GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6:Glu-->Ala]. This is the first report of hemoglobin G Makassar in Thailand.

Description

Chotmaihet Thangphaet.

Citation

Sangkitporn S, Rerkamnuaychoke B, Sangkitporn S, Mitrakul C, Sutivigit Y. Hb G Makassar (beta 6:Glu-Ala) in a Thai family. Journal of the Medical Association of Thailand. 2002 May; 85(5): 577-82