Pattern of inheritance in three sudden unexplained death syndrome ("Lai-tai") families.
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Date
2001-06-01
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Abstract
Sudden Unexplained Death Syndrome (SUDS) (or Lai-tai) is sudden death in previously healthy young adults without any structural cause of death from autopsy findings. Our previous data showed that familial SUDS is not X-linked recessive. The objective of this study was to determine the pattern of inheritance in familial SUDS using the ECG markers of Brugada syndrome (RBBB and ST-segment elevation in V1 to V3), SUDS and presumptive SUDS as phenotypes. We employed the standard 12-lead ECG and higher intercostal space (ICS) V1 to V3 (-V1 to -V3 and -2V1 to -2V3) leads ECG in SUDS relatives after procainamide and drew the pedigree. We studied 62 relatives of 9 SUDS victims who died in Singapore and selected 3 families (n = 34) for the procainamide test and ECG. The mean age was 36.4 +/- 23.6 years (4-78 years). Three SUDS families showed the same pattern of inheritance of autosomal dominant.
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Chotmaihet Thangphaet.
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Sangwatanaroj S, Ngamchareon C, Prechawat S. Pattern of inheritance in three sudden unexplained death syndrome ("Lai-tai") families. Journal of the Medical Association of Thailand. 2001 Jun; 84 Suppl 1(): S443-51