Decreased suppressor T-lymphocytes in women who received progestogen injections.
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Date
1992-08-01
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Abstract
Decreased levels of suppressor T-cells (CD8+) were found in 17 normal women who received progestogen (Depoprovera) injection, 150 mg intramuscularly every three months for contraceptive purposes, for more than 30 months. The helper: suppressor T-cells (CD4+ : CD8+ ratio) was significantly elevated in this group compared to 30 normal female controls. No significant change of T-lymphocyte was found in 53 normal women who received the injection for less than 30 months or who received combined oral contraceptive pills. In conclusion, long term progestogen injection induced a lowering of suppressor T-cell levels, which is the same immunological change found in several autoimmune diseases.
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Chotmaihet Thangphaet.
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Citation
Sridama V, Limpongsanurak S, Sritippayawan S, Youngprapakorn S. Decreased suppressor T-lymphocytes in women who received progestogen injections. Journal of the Medical Association of Thailand. 1992 Aug; 75(8): 479-82