Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis.
No Thumbnail Available
Date
2006-04-15
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The present investigation was undertaken to explore the anti-tumor promoting activity of Rosemarinus officinalis on two-stage skin carcinogenesis, induced by a single topical application of 7, 12-dimethylbenz(a)anthracene and promoted by treatment of croton oil for 15 weeks in Swiss albino mice. Oral administration of Rosemary leaf extract at a dose of 1,000 mg/ kg b. wt. / day at pre, peri and post-initiational phases, was found to be effective in decreasing the tumor incidence (50, 41.7, 58.3%, respectively) in comparison to the control (100%). Furthermore, the cumulative number of papillomas, tumor yield and tumor burden were also found to be reduced in R. officinalis-treated animals. This was associated with significant alteration in liver lipid peroxidation and glutathione (GSH) levels.
Description
Asian Pacific Journal of Cancer Prevention.
Keywords
Citation
Sancheti G, Goyal P. Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis. Asian Pacific Journal of Cancer Prevention. 2006 Apr-Jun; 7(2): 331-5