Basement membrane antibodies in Alport's syndrome.
No Thumbnail Available
Date
1991-06-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
By the indirect immunofluorescent technique, sera from patients with Alport's syndrome showed a reaction with the basement membrane of the capillary wall of glomeruli and peritubular vessels and nearby interstitial tissue of normal monkey and mouse kidney as a substrate. It also revealed bright staining to the matrix surrounding the clusters of EHS tumor cells and stromal tissues. These reactions were caused by autoantibodies present in these sera. These findings were supported by the detection of antilaminin, nidogen and anti collagen type VI in the sera by ELISA method. These evidences suggest that the Alport's patients developed stage of autoimmunity. The exact causes were not so clear, but seemed to be due to multiple factors.
Description
Published by the Allergy and Immunology Society of Thailand.
Keywords
Citation
Boonpucknavig S, Boonpucknavig V, Tapaneeyaolarn W. Basement membrane antibodies in Alport's syndrome. Asian Pacific Journal of Allergy and Immunology. 1991 Jun; 9(1): 31-7