Regulation of immunoglobulin secretion by T lymphocytes in human malaria.
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1986-06-01
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Abstract
In vitro studies were carried out on the nature of immunoglobulin synthesis and secretion by peripheral blood mononuclear leukocytes (PBMLs) and on the function of T and B cells from malaria patients. The mean values of secreted IgG and IgM concentrations of 22 malaria patient PMBLs were significantly higher than those of 20 normal PBMLs. When the suppressor T cell activity and the function of B cells in response to suppressor T cells were assayed by the cell co-culture technique, it was found that there was a decrease in suppressor T cell activity and the B cell function in response to normal suppressor T cells in malaria patients. The defects of these T and B cell functions may play some role in the immunological abnormalities seen in some malaria patients.
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Published by the Allergy and Immunology Society of Thailand.
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Makonkawkeyoon S, Kasinrerk W, Vithayasai V. Regulation of immunoglobulin secretion by T lymphocytes in human malaria. Asian Pacific Journal of Allergy and Immunology. 1986 Jun; 4(1): 13-7