Cell-mediated immunosuppression in mice by street rabies virus not restored by calcium ionophore or PMA.
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Date
1997-09-23
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Abstract
It is known that rabies virus can suppress the host immune system. In this study we demonstrate a depression of cell-mediated immunity in mice, peripherally infected with Thai street rabies virus. The cell-mediated cytolysis of spleen cells from mice increased transiently on day 5 after infection and declined rapidly thereafter until death. The proliferation of spleen cells stimulated with a T-cell mitogen such as phytohemagglutinin or concanavalin A, was significantly suppressed during the course of infection. There was also a marked suppression of IL-2 secretion in parallel with a decrease of the T-cell proliferative response to mitogen. The suppression of T-cell proliferation was not restored by treatment with a calcium ionophore (A 23187) or phorbol 12-myristate-13 acetate (PMA).
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Published by the Allergy and Immunology Society of Thailand.
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Citation
Kasempimolporn S, Saengseesom W, Mitmoonpitak C, Akesowan S, Sitprija V. Cell-mediated immunosuppression in mice by street rabies virus not restored by calcium ionophore or PMA. Asian Pacific Journal of Allergy and Immunology. 1997 Sep; 15(3): 127-32