Identification of tumor markers for cholangiocarcinoma and evaluation of their diagnostic potential.
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Date
1994-06-01
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Abstract
Results obtained from studies using experimental animal model clearly showed that (1) A marker(s) for CCA does exist; 2) This marker is a glycoprotein with a molecular weight of 200 kDa; (3) It is produced and secreted in vitro by tumor cell lines; (4) It is highly immunogenic in mice and the MAb specific for this antigen is directed against the carbohydrate moiety; (5) This tumor antigen can be detected in serum and bile of tumor-bearing animals by a sandwich ELISA employing this MAb; (6) Kinetic studies show a gradual elevation of this antigen during tumor development; and (7) The elevation of this antigen can be detected at a time when no pathological changes have yet taken place, as judged by microscopic examination. Preliminary work from the human counterpart using human cholangiocarcinoma cell line showed promising results. CCA-specific antigen could be similarly identified and the MAbs produced were highly specific for this 160 kDa antigen.
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Published by the Allergy and Immunology Society of Thailand.
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Citation
Sirisinha S, Prempracha N, Tengchaisri T, Hongsrijinda N, Chawengkirttikul R, Chinchai T. Identification of tumor markers for cholangiocarcinoma and evaluation of their diagnostic potential. Asian Pacific Journal of Allergy and Immunology. 1994 Jun; 12(1): 73-81