The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients.
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Date
1992-06-01
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Abstract
Certain adverse reactions to aspirin (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs) and pyrazoline derivatives resemble IgE-mediated hypersensitivity. However, convincing evidence of antigen-antibody interactions or of the inhibition of the cyclooxygenase pathway of arachidonic acid metabolism leading to an increase in the generation of leukotrienes (LTs) and a decrease in the generation of prostaglandins (PGs) was not fully demonstrated. In this study, two types of specific IgE antibodies have been found in 27 serum samples from 28 ASA-sensitive patients with salicyloyl-discs and O-methylsalicyloyl-discs by Radio Allergo Sorbent Tests (RAST). The positive rates were 96.4% and 71.4%, respectively. In contrast, no positive results could be found in 10 normal donors without ASA sensitivity after ingestion of ASA 500 mg/day for 14 days. Further investigation of the chemical structure of epitopes was done by cross inhibition studies. Our results are an increasing evidence in favour of an IgE-dependent mechanism in patients suffering from ASA sensitivity. Hopefully, the determination of specific IgE antibodies will be a safe diagnostic method of ASA sensitivity in vitro.
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Published by the Allergy and Immunology Society of Thailand.
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Citation
Zhu D, Becker WM, Schulz KH, Schubeler K, Schlaak M. The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients. Asian Pacific Journal of Allergy and Immunology. 1992 Jun; 10(1): 25-32