Nebulized salbutamol (Asmasal) in Thai children with asthma: comparison of three doses.
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Date
1994-06-01
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Abstract
Eleven moderate-to-severe asthmatic children 5-11 years of age who were in stable condition were given (randomly, double-blind) nebulized salbutamol sulfate (Asmasal) inhalation therapy at doses of 0.1, 0.2 and 0.3 mg/kg body weight on separated days. All three doses of nebulized solution resulted in clinical improvement and improvement of lung function (FEV1, FVC, PEFR and FEF25-75%). A dose of 0.3 mg/kg produced greatest improvement and longest duration of improvement in FEV1 and PEFR, but the change was statistically significant only in PEFR at 60 minutes (p < 0.05). Five children experienced mild tremors. There were no significant changes in heart rate or blood pressure at any dose. It is concluded that a nebulized solution of salbutamol sulfate at a dose of 0.1-0.3 mg/kg is useful for treatment of asthma in Thai children, with very mild side effects.
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Published by the Allergy and Immunology Society of Thailand.
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Citation
Visitsuntorn N, Wichienwattanachai V, Vichyanond P, Kerdsomnuk S, Tuchinda M. Nebulized salbutamol (Asmasal) in Thai children with asthma: comparison of three doses. Asian Pacific Journal of Allergy and Immunology. 1994 Jun; 12(1): 7-13