A study on CNS-side effects of mequitazine, an H1-specific antihistamine in healthy Thai volunteers.
No Thumbnail Available
Date
1990-06-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Mequitazine is a potent, non-sedative, long-acting H1-specific antihistamine proven to be a better therapeutic drug than other conventional antihistamines. It is also reported by many authors that the drug produces less sedative or other depressive actions on the central nervous system than other antihistamines. In order to evaluate the advantage of this drug in Asian people, an assessment of side effects of mequitazine, in comparison with chlorpheniramine, on the central nervous system was done in 20 healthy Thai volunteers, 10 males and 10 females 23-39 years of age, using a double blind crossover placebo controlled trial. Various subjective tests: alertness scale rating, visual analogue scale rating as well as objective tests: card sorting, glassbead picking and estimation of reaction time, were performed. There were no significant differences in side effects on the central nervous system between mequitazine and the placebo, whereas chlorpheniramine did produce side effects.
Description
Published by the Allergy and Immunology Society of Thailand.
Keywords
Citation
Dhorranintra B, Sriprasong T, Limsuvan S, Klyprayong S. A study on CNS-side effects of mequitazine, an H1-specific antihistamine in healthy Thai volunteers. Asian Pacific Journal of Allergy and Immunology. 1990 Jun; 8(1): 39-44