Modulation of lymphocyte proliferation by murine liver extract.
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1987-06-01
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Abstract
Murine liver extract (LEx) purified by ammonium sulfate (45-70% saturation) possesses a strong inhibitory effect on human lymphocyte proliferation. We have shown that the inhibitory effect of LEx is not via a cytotoxic effect and that it is proportional to the length of incubation with LEx. Mitogen-prestimulated lymphocytes are more resistant to LEx inhibition than cells not prestimulated. B cells stimulated by PWM are more susceptible to LEx-induced inhibition than PHA- or Con A-stimulated T cells. In Con A cultures, there may be a population of cells more resistant to LEx inhibition. This population is not yet identified. The degree of reversibility of LEx inhibition was different in cells prestimulated by different mitogens. The inhibitory activity of LEx decreased in the presence of an increasing number of cells in the culture.
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Published by the Allergy and Immunology Society of Thailand.
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Su HL, Huang MH, Yu CL, Han SH, Chiang BN, Wang SR. Modulation of lymphocyte proliferation by murine liver extract. Asian Pacific Journal of Allergy and Immunology. 1987 Jun; 5(1): 17-24