Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
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Date
1992-03-01
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Abstract
Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days. On a drug-sensitive Plasmodium berghei ANKA strain, pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). On a moderately chloroquine-resistant P. berghei NS line, the order of effects was the same, PND greater than ADQ greater than MFQ greater than QHS. On a highly pyronaridine-resistant P. berghei RP line, ADQ, MFQ and QHS showed cross resistance with PND.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Citation
Shao BR, Ye XY, Chu YH. Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Mar; 23(1): 59-63