Sequence diversity of the C-terminal region of Plasmodium falciparum merozoite surface protein 1 in southern Iran.
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Date
2009-01-28
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Abstract
The C-terminal region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum is a strong vaccine candidate as it is associated with immunity to the parasite. This corresponds approximately to the conserved 17th block of the gene and is composed of two EGF- like domains. These domains exhibit only four single amino acid substitutions which show several potential variants in this region of the gene. As the variations might be important for a regional vaccine design, a study was carried out to determine the variations present in P. falciparum isolates from southern Iran. Besides the usual E-T-S-R-L and the Q-K-N-G-F types, we found Q-T-S-R-L, E-K-N-G-F, E-T-S-G-L, Z-T-S-G-L and Z-T-S-R-L types, where Z was E or Q signifying the presence of mixed clones in single isolates.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Zamani Z, Razavi MR, Sadeghi S, Naddaf S, Pourfallah F, Mirkhani F, Arjmand M, Feizhaddad H, Rad ME, Tameemi M, Assmar M. Sequence diversity of the C-terminal region of Plasmodium falciparum merozoite surface protein 1 in southern Iran. The Southeast Asian Journal of Tropical Medicine and Public Health. 2009 Jan; 40(1): 1-9