Ivermectin and diethylcarbamazine trials in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani.

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Date
1992-06-01
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Abstract
Clinical trials of Ivermectin in single oral doses of 200, 400, and 1,000 mg/kg body weight or in multiple doses of 200 mg/kg body weight for 5 consecutive days were performed in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. Optimal microfilaricidal effect occurred at 200 mg/kg body weight. The drug was less effective than diethylcarbamazine in this animal model for human filariasis but had no adverse effects.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Kurniawan A, Sartono E, Setiowati WE, Supali T, Wibowo H, Purnomo , Rukmono B, Partono F. Ivermectin and diethylcarbamazine trials in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Jun; 23(2): 288-92
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https://imsear.searo.who.int/handle/123456789/34852
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Southeast Asian Journal of Tropical Medicine and Public Health