Sporozoite-induced Plasmodium cynomolgi infections in captive born Macaca fascicularis.
No Thumbnail Available
Date
1984-03-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Capability of captive born cynomolgus monkeys to substitute for rhesus in the Plasmodium cynomolgi radical curative antimalarial drug development model was examined. Eighteen monkeys divided into 3 groups were given standard or high doses of sporozoites intravenously. One group of 4 received 0.8 - 1.6 X 10(6) and a second group of 8 received 0.3 - 1.0 X 10(7) sporozoites. The third group of 6 was splenectomized and then received 3.0 - 4.0 X 10(6). The 2 groups of intact monkeys developed a persistent low level parasitemia; however, gametocyte production was poor. The splenectomized group developed a persistent parasitemia with a higher mean, which more closely resembled rhesus parasitemias. A high, post-patent leukocytosis consisting primarily of lymphocytes was observed in this group. Good gametocyte production resulted in the splenectomized group and oocysts were produced from all lots of Anopheles dirus which fed on them. Following clearance of blood forms, relapse potential was demonstrated in the 2 splenectomized monkeys tested. In this study the splenectomized captive born cynomolgus appeared to be capable of supplementing rhesus as an antimalarial drug testing model.
Description
The Southeast Asian Journal of Tropical Medicine and Public Health.
Keywords
Citation
Ward GS, Hansukjariya P, Wongsepradit S, Andre RG, Davidson DE. Sporozoite-induced Plasmodium cynomolgi infections in captive born Macaca fascicularis. The Southeast Asian Journal of Tropical Medicine and Public Health. 1984 Mar; 15(1): 12-7