Field performance of VAQTA (inactivated, purified hepatitis a vaccine) in Chinese children in Jiangsu.
Loading...
Files
Date
2004-12-27
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In Jiangsu, 30% of children between the ages of 5 and 8 years test seropositive for hepatitis A. The safety, tolerability, and immunogenicity of a 2-dose regimen (0, 6 months) of VAQTA (0.5 ml of 25U) administered IM in 50 healthy children aged 5 to 8 years without prior serological screening was evaluated. Blood samples were collected prior to the first dose and after each additional dose of VAQTA to determine the initial anti-HAV serostatus and response rates to the vaccine. Twelve children (24%) were initially seropositive and 38 (76%) were initially seronegative. Four weeks after the primary dose of VAQTA, 34 of the 38 subjects (89.5%, 95% CI 75 to 97) were anti-HAV seropositive. The geometric mean titer was 33.1 mIU/ml (95% CI 22.4 to 49.0). After the booster dose at 6 months, all the subjects were seropositive (37/37), giving a seroconversion of 100% (95% CI: 90, 100). The geometric mean titer was 7585.8 mIU/ml (95% CI: 5623.4 to 10,471.3). Adverse experiences were generally mild and transient. Results of this study are consistent with results from a previous double-blind randomized trial of this vaccine and confirm that VAQTA is highly immunogenic, and generally well-tolerated.
Description
The Southeast Asian Journal of Tropical Medicine and Public Health.
Keywords
Citation
Wang H, Chen X, Chen Z, Lu W, Poerschke G, Eves K, Gress J, Kuter B. Field performance of VAQTA (inactivated, purified hepatitis a vaccine) in Chinese children in Jiangsu. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Dec; 35(4): 949-53