Proguanil/sulfamethoxazole malaria chemoprophy-laxis on the Thai-Cambodian border.
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Date
1991-03-01
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Abstract
383 Thai soldiers on the Thai-Cambodian border were entered into a randomized malaria chemoprophylactic trial. Proguanil (200 mg/day) combined with sulfamethoxazole (1000 or 1500 mg/day) were compared to a standard combination of weekly pyrimethamine/dapsone (Maloprim). Men receiving proguanil/sulfamethoxazole had a significantly lower malaria attack rate than those taking pyrimethamine/dapsone. This was true of both the first five-week phase in which 1000 mg of sulfamethoxazole was used (0.11 vs 0.26; p less than 0.001) and in the second ten weeks in which 1500 mg of sulfamethoxazole was used (0.13 vs 0.30; p less than 0.001). Combined relative efficacy indicated that proguanil/sulfamethoxazole was better than pyrimethamine/dapsone by 64% for Plasmodium vivax and by 38% for P. falciparum. Unenforced compliance as measured by returned pills was greater than 86% in both groups. No serious drug side-effects were observed. Proguanil/sulfamethoxazole may represent a useful chemoprophylactic option in areas of multiple drug-resistant malaria.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Karwacki JJ, Shanks GD, Suriyamongkol V, Watanasook C. Proguanil/sulfamethoxazole malaria chemoprophy-laxis on the Thai-Cambodian border. The Southeast Asian Journal of Tropical Medicine and Public Health. 1991 Mar; 22(1): 77-80