Study on serum transcobalamin II in patients with murine typhus.
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Date
2006-05-06
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Abstract
We measured the serum transcobalamin II in murine typhus- infected patients (n = 16) admitted to the Hospital for Tropical Diseases in 1996-1997, compared with healthy controls (n = 60). The results showed that the transcobalamin II (TCII) and total serum unsaturated vitaminB12 binding capacity (UBBC) in patients with murine typhus (2,126.5 pg/ml, range 1,262-4,568 and 3,771.5 pg/ml, range 1,576-6,763 pg/ml) were statistically significantly higher than normal subjects (987.5 pg/ml, range 678-2,000 pg/ml and 1,402 pg/ml, range 932-2,470 ml) (p<0.001). Serum TCII levels in patients (63%) were elevated during the febrile period and returned to normal post-treatment. These findings suggest that patients with murine typhus had stimulation of reticulo-endothelial system, spleen, mesenteric lymph nodes, liver and skin and then released TCII into the blood circulation. The elevation in TCII may be used for confirming a diagnosis of murine typhus.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Cheeramakara C, Songmeang K, Nakosiri W, Suthisai N, Nontprasert A, Areekul S. Study on serum transcobalamin II in patients with murine typhus. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 ; 37 Suppl 3(): 145-8