Interaction between endothelial cells and thalassemic red cells in vitro.
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1992-03-01
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Abstract
Erythrocytes from 45 patients with thalassemia and/or hemoglobinopathies were studied for their cytoadherence property to the vascular endothelial cells in vitro. In plasma free medium, erythrocytes from patients with beta-thal/Hb E both splenectomized and nonsplenectomized, HbH diseases (alpha-thal 1/alpha-thal 2 and alpha-thal 1/Hb Constant Spring genotypes) and homozygous Hb E subjects bind to endothelial cells at a greater number as compared to the binding cell number of normal erythrocytes (p-value < 0.05 in all types). Addition of autologous platelet-rich plasma or whole blood to the culture system causes further increase in the number of adhering beta-thalassemia red cells. Platelet-rich plasma had more enhancement effect than the whole blood. However, no such enhancement of both platelet-rich plasma and whole blood was demonstrated in the culture of normal or alpha-thalassemia erythrocytes. Increased binding between red cells and endothelial cells may contribute to the greater risk of vascular occlusion in thalassemic patients.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Butthep P, Bunyaratvej A, Kitaguchi H, Funahara Y, Fucharoen S. Interaction between endothelial cells and thalassemic red cells in vitro. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 ; 23 Suppl 2(): 101-4