Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
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Date
1993-03-01
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Abstract
Hemostatic profiles and cardiac enzymes were studied in 55 acute myocardial infarct (AMI) patients to assess SK and rt-PA therapy. Hypofibrinogenemia occurred 85% in SK group and 55% in rt-PA group with high FDP and D-Dimer, indicating systemic fibrinogenolysis and local crosslinked fibrin clot lysis. The incidence of bleeding in SK and rt-PA groups combined with anticoagulants were the same but lower in rt-PA with antiplatelet. The mean FDP was significantly higher in the bleeding group (p < 0.01). Cardiac enzymes: CK, CK-MB peak values indicated reperfusion were 26.6%, 60% and 90% in conventional, SK and rt-PA therapy, respectively. Early and late occlusion did not occur either in SK or rt-PA followed by anticoagulants. Late occlusion was found in patients treated with rt-PA and antiplatelet. Mortality rate was 20% in conventional therapy.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Talalak P, Chaithiraphan S, Opartkiattikul N, Leowattana W, Sangtawesin W, Tresukosol D. Laboratory assessment of thrombolytic therapy in acute myocardial infarction. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 ; 24 Suppl 1(): 144-8