Transient, acquired glucose-6-phosphate dehydrogenase deficiency in Thai children with typhoid fever.
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Date
1982-03-01
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Abstract
Seventy nine children with typhoid fever were studied, 45 were males and 34 were females. There were 9 out of 45 males patients (20%) who had definite G-6-PD deficiency of whom 3 had acute intravascular hemolysis. The rest of the patients had transient low enzyme activity during the first few weeks of their illness, with reticulocytopenia. Their G-6-PD activities rose up to normal level later in the course of the disease while the reticulocytes were also increased. This study demonstrated that even in normal G-6-PD subjects, typhoid fever can cause transient, acquired low G-6-PD level due to bone marrow suppression. It was suggested from this study that quantitative G-6-PD assay was more useful and sensitive than the screening method and that long term follow up is needed in the case that had unexplained low G-6-PD activity.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Citation
Tanphaichitr VS, Suvatte V, Mahasandana C, Tuchinda S. Transient, acquired glucose-6-phosphate dehydrogenase deficiency in Thai children with typhoid fever. The Southeast Asian Journal of Tropical Medicine and Public Health. 1982 Mar; 13(1): 105-9