Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine.

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1990-05-01
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Abstract
The absorption of 125I-labelled bovine serum albumin, gamma-globulin and alpha-lactalbumin was considerably enhanced in G. lamblia infected Swiss mice intestine compared to uninfected controls. The binding of 125I-proteins to brush border membrane was however, significantly (P less than 0.01) low in infected animals. Kinetic studies with gamma-globulin binding to brush borders revealed a decrease in the number of binding sites in infected animals (1.52) compared to controls (2.86 micrograms/mg protein) with no change in the affinity constant (47.60 micrograms/ml) under these conditions. These findings suggest that G. lamblia infection in mice leads to enhanced macromolecular absorption which seems unrelated to the binding of proteins to epithelial cell surface.
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Mahmood S, Ganguly NK, Mahajan RC, Walia BN. Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine. Indian Journal of Medical Research. 1990 May; 91(): 218-22
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https://imsear.searo.who.int/handle/123456789/25648
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Indian Journal of Medical Research