Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics – A Single-Center Experience From a Tropical Setting
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Date
2023-05
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objective: Identifying clinical and laboratory indicators that differentiate multisystem inflammatory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting. Methods: Review of hospital records done in a tertiary care exclusive children’s hospital for children admitted from April, 2020 till June, 2021. Laboratory values, severe acute respiratory syndrome coronavirus (SARS-CoV-2) serological status, and clinical signs and symptoms of patients with MIS-C, and those with similar presentations were analyzed. Results: 114 children fulfilled the inclusion criteria (age group of 1 mo-18 y) for whom a diagnosis of MIS-C was considered in the emergency room based on the clinical features. Among them, 64 children had the final diagnosis of MIS-C, and the remaining 50 children had confirmatory evidence of infections mimicking MIS-C such as enteric fever, scrub typhus, dengue and appendicitis. Conclusion: Older age group, presence of mucocutaneous symptoms, very high C-reactive protein, neutrophilic leukocytosis, abdominal pain and absence of hepatosplenomegaly favor a diagnosis of MIS-C.
Description
Keywords
Dengue, Enteric fever, Scrub typhus, SARS-CoV-2
Citation
Balasubramanian S, Sankar Janani, Dhanalakshmi K, Raj S Lakshan, Nandakumar Divya, Ramanan AV, Chandy Sara. Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics – A Single-Center Experience From a Tropical Setting. Indian Pediatrics. 2023 May; 60(5): 377-380