Assessment of Causality in Hospitalized Children With AminoglycosideRelated Nephrotoxicity
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Date
2022-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objectives: To evaluate the incidence of aminoglycoside-related nephrotoxicity and ascertain drug causality and its risk factors. Methods: This prospective study was conducted from January, 2019 to January, 2021, and recruited 110 consecutively admitted children aged 1 month to 12 years, receiving aminoglycosides for ?4 days. Drug causality was assessed using Liverpool adverse drug reaction causality assessment tool. Results: 42 (38.2%) children developed acute kidney injury (AKI), with 71 (64.5%) having composite nephrotoxicity (AKI and/or tubular-dysfunction). Only 17 (15.5%) had AKI definitively attributable to aminoglycosides. Hypotension [OR 0.016 (95% CI 0.01-0.71), P=0.03], PRISM-III score 20-29% [OR 55.48 (95% CI 3.66-840.53), P=0.004] and post-surgery patients [OR 3.2 (95% CI 1.01-10.1), P=0.047] were independent predictors of AKI. Conclusions: Only a small proportion of children receiving aminoglycosides had AKI definitively attributable to the drug.
Description
Keywords
Acute kidney injury, Liverpool assessment tool, Tubular dysfunction
Citation
Sravani Madhileti, Krishnamurthy Sriram, Parameswaran Narayanan, Rajappa Medha. Assessment of Causality in Hospitalized Children With AminoglycosideRelated Nephrotoxicity. Indian Pediatrics. 2022 Mar; 59(3): 226-229