Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening
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Date
2022-11
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objective: The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening. Methods: We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (n=24) were compared with index celiacs (n=186). Results: At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (?10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients. Conclusions: Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.
Description
Keywords
Asymptomatic, Serology, Silent disease
Citation
Akkelle Bilge S, Volkan Burcu, Tutar Engin, Ertem Deniz. Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening. Indian Pediatrics. 2022 Nov; 59(11): 867-870