Necrosis of uveal melanoma post-COVID-19 vaccination
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Date
2022-05
Journal Title
Journal ISSN
Volume Title
Publisher
All India Ophthalmological Society
Abstract
A 49?year?old Indian male presented with rapidly progressive vision loss 1 day after receiving the second dose of BNT162b2 mRNA coronavirus disease 2019 (COVID?19) vaccine (Pfizer?BioNTech, NY, USA). The eye had secondary angle closure glaucoma, bullous retinal detachment, and massive intraocular hemorrhage. Ultrasound showed an ill?defined subretinal mass with moderate internal reflectivity. Magnetic resonance imaging (MRI) confirmed an enhancing heterogeneous subretinal mass. Histopathology showed a necrotic melanocytic lesion arising from the posterior edge of the ciliary body and choroid. Necrotic uveal melanoma was confirmed after expert histopathology opinion. Uveal melanomas can rarely present with tumor necrosis following mRNA COVID?19 vaccination.
Description
Keywords
COVID?19 vaccination, necrotic melanoma, spontaneous necrosis, uveal melanoma
Citation
Wagle Ajeet M., Wu Bing Cheng, Gopal Lingam, Sundar Gangadhara. Necrosis of uveal melanoma post-COVID-19 vaccination. Indian Journal of Ophthalmology. 2022 May; 70(5): 1837-1840