Impact of Empagliflozin Add-on Therapy on Quality of Life in Patients of Type 2 Diabetes Mellitus with Hypertension: A Prospective Study
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Date
2022-11
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer – Medknow
Abstract
Background: Diabetes has a negative impact on patient’s quality of life (QoL). Comorbidities and polypharmacy further worsen their QoL. Thus, in addition to glycemic control, assessment of QoL is also gaining importance. Objective: The objective of this study was to evaluate QoL in patients of type 2 diabetes mellitus (T2DM) with hypertension after add?on empagliflozin to triple drug therapy (metformin, teneligliptin, and glimepiride). Materials and Methods: A prospective research was done on T2DM patients with hypertension, who visited a tertiary care referral institute’s endocrine outpatient clinic. For 3 months, empagliflozin, 25 mg once daily, was administered as an add?on treatment with metformin, teneligliptin, and glimepiride. In addition to clinical assessment, an Urdu-translated QoL instrument for Indian diabetes patients was used to conduct QoL study. The QoL outcomes prior to empagliflozin add?on were compared with those obtained at the conclusion of the 3 months of treatment. Results: Empagliflozin as an add?on therapy significantly improved various aspects of QoL like role limitation due to physical health, physical endurance, general health, symptom botherness, financial worries, emotional/mental health, and diet satisfaction (P < 0.001). It also improved glycemic and blood pressure parameters significantly. Conclusion: QoL is an essential measure with respect to patient?centered treatment approach. Empagliflozin, as an add?on medication, improved QoL, glycemic parameters and blood pressure in T2DM patients with hypertension. It can be recommended as an add?on, but more research with a larger sample size is required.
Description
Keywords
Empagliflozin, hypertension, quality of life instrument in diabetes, type 2 diabetes
Citation
Najar IA, Masoodi SR, Mir SA, Bhat MH, Patyar RR, Patyar S.. Impact of Empagliflozin Add-on Therapy on Quality of Life in Patients of Type 2 Diabetes Mellitus with Hypertension: A Prospective Study. Indian Journal of Public Health. 2022 Nov; 66(1): 41-44